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gabazine hydrobromide  (Tocris)
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Spontaneous postsynaptic currents (sPSCs) and spontaneous excitatory postsynaptic currents (sEPSCs) of hippocampal CA1 pyramidal neurons; effects of Bz-ATP. sEPSCs were recorded in the continuous presence of <t>gabazine</t> (10 µM). Bz-ATP (300 µM) effects on the amplitude and frequency of the spontaneous currents in low X 2+ aCSF. (A) Representative recordings or sPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (B) Representative, averaged sPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (C) Mean±S.E.M. sPSC amplitudes (left panel) and mean±S.E.M. frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (D) Percentage changes of sPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test), as calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells. (E) Representative recordings or sEPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (F) Representative, averaged sEPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (G) Mean±S.E.M. sEPSC amplitudes (left panel) and mean±S.E.M. sEPSC frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (H) Percentage changes of sEPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test) were calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells.
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Spontaneous postsynaptic currents (sPSCs) and spontaneous excitatory postsynaptic currents (sEPSCs) of hippocampal CA1 pyramidal neurons; effects of Bz-ATP. sEPSCs were recorded in the continuous presence of <t>gabazine</t> (10 µM). Bz-ATP (300 µM) effects on the amplitude and frequency of the spontaneous currents in low X 2+ aCSF. (A) Representative recordings or sPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (B) Representative, averaged sPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (C) Mean±S.E.M. sPSC amplitudes (left panel) and mean±S.E.M. frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (D) Percentage changes of sPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test), as calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells. (E) Representative recordings or sEPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (F) Representative, averaged sEPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (G) Mean±S.E.M. sEPSC amplitudes (left panel) and mean±S.E.M. sEPSC frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (H) Percentage changes of sEPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test) were calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells.
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95531 hydrobromide  (Tocris)
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Spontaneous postsynaptic currents (sPSCs) and spontaneous excitatory postsynaptic currents (sEPSCs) of hippocampal CA1 pyramidal neurons; effects of Bz-ATP. sEPSCs were recorded in the continuous presence of <t>gabazine</t> (10 µM). Bz-ATP (300 µM) effects on the amplitude and frequency of the spontaneous currents in low X 2+ aCSF. (A) Representative recordings or sPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (B) Representative, averaged sPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (C) Mean±S.E.M. sPSC amplitudes (left panel) and mean±S.E.M. frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (D) Percentage changes of sPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test), as calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells. (E) Representative recordings or sEPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (F) Representative, averaged sEPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (G) Mean±S.E.M. sEPSC amplitudes (left panel) and mean±S.E.M. sEPSC frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (H) Percentage changes of sEPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test) were calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells.
95531 Hydrobromide, supplied by Tocris, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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gabazine  (Tocris)
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Spontaneous postsynaptic currents (sPSCs) and spontaneous excitatory postsynaptic currents (sEPSCs) of hippocampal CA1 pyramidal neurons; effects of Bz-ATP. sEPSCs were recorded in the continuous presence of <t>gabazine</t> (10 µM). Bz-ATP (300 µM) effects on the amplitude and frequency of the spontaneous currents in low X 2+ aCSF. (A) Representative recordings or sPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (B) Representative, averaged sPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (C) Mean±S.E.M. sPSC amplitudes (left panel) and mean±S.E.M. frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (D) Percentage changes of sPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test), as calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells. (E) Representative recordings or sEPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (F) Representative, averaged sEPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (G) Mean±S.E.M. sEPSC amplitudes (left panel) and mean±S.E.M. sEPSC frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (H) Percentage changes of sEPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test) were calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells.
Gabazine, supplied by Tocris, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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sr95531 hydrobromide  (Tocris)
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Spontaneous postsynaptic currents (sPSCs) and spontaneous excitatory postsynaptic currents (sEPSCs) of hippocampal CA1 pyramidal neurons; effects of Bz-ATP. sEPSCs were recorded in the continuous presence of <t>gabazine</t> (10 µM). Bz-ATP (300 µM) effects on the amplitude and frequency of the spontaneous currents in low X 2+ aCSF. (A) Representative recordings or sPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (B) Representative, averaged sPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (C) Mean±S.E.M. sPSC amplitudes (left panel) and mean±S.E.M. frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (D) Percentage changes of sPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test), as calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells. (E) Representative recordings or sEPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (F) Representative, averaged sEPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (G) Mean±S.E.M. sEPSC amplitudes (left panel) and mean±S.E.M. sEPSC frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (H) Percentage changes of sEPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test) were calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells.
Sr95531 Hydrobromide, supplied by Tocris, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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95531 hydrobromide gabazine  (Tocris)
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Spontaneous postsynaptic currents (sPSCs) and spontaneous excitatory postsynaptic currents (sEPSCs) of hippocampal CA1 pyramidal neurons; effects of Bz-ATP. sEPSCs were recorded in the continuous presence of <t>gabazine</t> (10 µM). Bz-ATP (300 µM) effects on the amplitude and frequency of the spontaneous currents in low X 2+ aCSF. (A) Representative recordings or sPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (B) Representative, averaged sPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (C) Mean±S.E.M. sPSC amplitudes (left panel) and mean±S.E.M. frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (D) Percentage changes of sPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test), as calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells. (E) Representative recordings or sEPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (F) Representative, averaged sEPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (G) Mean±S.E.M. sEPSC amplitudes (left panel) and mean±S.E.M. sEPSC frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (H) Percentage changes of sEPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test) were calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells.
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gabazine sr 95531 hydrobromide tocris bioscience  (Tocris)
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Spontaneous postsynaptic currents (sPSCs) and spontaneous excitatory postsynaptic currents (sEPSCs) of hippocampal CA1 pyramidal neurons; effects of Bz-ATP. sEPSCs were recorded in the continuous presence of <t>gabazine</t> (10 µM). Bz-ATP (300 µM) effects on the amplitude and frequency of the spontaneous currents in low X 2+ aCSF. (A) Representative recordings or sPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (B) Representative, averaged sPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (C) Mean±S.E.M. sPSC amplitudes (left panel) and mean±S.E.M. frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (D) Percentage changes of sPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test), as calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells. (E) Representative recordings or sEPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (F) Representative, averaged sEPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (G) Mean±S.E.M. sEPSC amplitudes (left panel) and mean±S.E.M. sEPSC frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (H) Percentage changes of sEPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test) were calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells.
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Spontaneous postsynaptic currents (sPSCs) and spontaneous excitatory postsynaptic currents (sEPSCs) of hippocampal CA1 pyramidal neurons; effects of Bz-ATP. sEPSCs were recorded in the continuous presence of gabazine (10 µM). Bz-ATP (300 µM) effects on the amplitude and frequency of the spontaneous currents in low X 2+ aCSF. (A) Representative recordings or sPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (B) Representative, averaged sPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (C) Mean±S.E.M. sPSC amplitudes (left panel) and mean±S.E.M. frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (D) Percentage changes of sPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test), as calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells. (E) Representative recordings or sEPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (F) Representative, averaged sEPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (G) Mean±S.E.M. sEPSC amplitudes (left panel) and mean±S.E.M. sEPSC frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (H) Percentage changes of sEPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test) were calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells.

Journal: bioRxiv

Article Title: P2X7 receptor-mediated astrocytic atrophy in the hippocampus of mice after status epilepticus

doi: 10.64898/2026.04.16.718853

Figure Lengend Snippet: Spontaneous postsynaptic currents (sPSCs) and spontaneous excitatory postsynaptic currents (sEPSCs) of hippocampal CA1 pyramidal neurons; effects of Bz-ATP. sEPSCs were recorded in the continuous presence of gabazine (10 µM). Bz-ATP (300 µM) effects on the amplitude and frequency of the spontaneous currents in low X 2+ aCSF. (A) Representative recordings or sPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (B) Representative, averaged sPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (C) Mean±S.E.M. sPSC amplitudes (left panel) and mean±S.E.M. frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (D) Percentage changes of sPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test), as calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells. (E) Representative recordings or sEPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (F) Representative, averaged sEPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (G) Mean±S.E.M. sEPSC amplitudes (left panel) and mean±S.E.M. sEPSC frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (H) Percentage changes of sEPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test) were calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells.

Article Snippet: The drugs used were the following: JNJ-47965567, gabazine hydrobromide (Tocris Biosciences, Bristol, UK); kainic acid hydrate (MedChem Express, Monmouth Junction, NJ, USA); diazepam (Shanghai Xudong Haipu Pharmaceutical Co., Shanghai, China).

Techniques: